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Even when standard serum B12 and folate levels appear normal, functional deficiencies in 5-methyltetrahydrofolate (5-MTHF) and methylcobalamin can limit mitochondrial ATP production and neurotransmitter synthesis, potentially driving persistent fatigue symptoms (13)

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et al., 2023), sinapic acid (Qian et al., 2020), schisandrin B (Zhang et al., 2021), and wedelolactone (Wei et al., 2017)], 9 terpenoids [brusatol (Zhou et al., 2018), bryodulcosigenin (Li et al., 2022), ginsenoside Rk3 (Tian et al., 2020), ginsenoside Rg3 (Liu et al., 2023), ginsenoside Rd (Liu C

236 JMJD6, another JmjC-containing iron and 2-oxoglutarate-dependent dioxygenase, can demethylate histone H3 arginine 2 (H3R2me2) and histone H4 arginine 3 (H4R3me2) as an arginine demethylase by removing methyl groups

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