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Our study was performed in a large cohort of 500 treatment-nave patients eligible for HCV drug clinical trials and infected with either subtype 1a or 1b, based on the reference method, i.e

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A precursor for cellular methylation reactions, methionine plays an important role in lipid metabolism, polyamine synthesis, immune function, heavy metal chelation, and maintenance of redox balance.4Conversely, dietary methionine restriction in rodents increased energy expenditure, improved insulin resistance, and enhanced lipolysis and fatty acid oxidation in adipose tissue.[1] The lipotropic effects of methionine may be attributed to its metabolite S-adenosyl methionine (SAM)