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The elevated homocysteine creates further oxidative stress and neuroinflammation, which in turn damages the myelin sheath and worsens the cognitive dysfunction and neuropathy

A further limitation was that there was a lack of racial or ethnic diversity in the hepatic impairment study

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Western blot analysis confirmed Cre-induced expression of FLAG-tagged HDAC9 and increased HDAC9 protein levels in the hippocampus compared with control AAV-injected mice (Fig