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Chronically high levels of leptin (such as from overeating) can cause leptin resistance

Wang D, Zhang L, Zhang Y, Zhang Y, Xu S
Zhang L, Xu B, Wu T, Wen MX, Fan LX, Feng ZZ, Paoletti E (2017) Transcriptomic analysis of Pak Choi under acute ozone exposure revealed regulatory mechanism against ozone stress

A previous study demonstrated that WT -syn is beneficial to dopaminergic neurons, whereas overexpression of WT -syn in the presence of DA induce dopaminergic neuronal damage [120, 122]

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