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Deciphering physiological roles of isoenzymes is often challenging

Others might theoretically conflict with metabolic pathways already being modulated

In addition, NRF2-addicted cells exhibit further elevated expression of SLC7A11 , GCLC, and GCLM due to additional cooperative input to the NRF2-mediated transcriptional activation

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[DOI] [PubMed] [Google Scholar] 115.Ge EJ, Bush AI, Casini A, Cobine PA, Cross JR, DeNicola GM, Dou QP, Franz KJ, Gohil VM, Gupta S, Kaler SG, Lutsenko S, Mittal V, Petris MJ, Polishchuk R, Ralle M, Schilsky ML, Tonks NK, Vahdat LT, Van Aelst L, Xi D, Yuan P, Brady DC, Chang CJ