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While prompt and efficient healing of skin wounds is essential to maintaining the vital barrier function of the skin, a pathological wound healing response can result in abnormal extracellular matrix (ECM) deposition and diminished degradation, ultimately leading to scarring and fibrosis (Figure 2)

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Meanwhile, the high dose (1.5 mg/kg) of vitamin B12 treatment showed better effectiveness than the 0.5 mg/kg dose in TBI mice

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