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Early AMD patients have high levels of oxidized glutathione (glutathione disulfide), a biomarker for AMD
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found that canopy FGF signaling regulator 2 (CNPY2) activates the PERK/ATF4/CHAC1 signaling pathway to promote ferroptosis, thereby leading to tubular injury in diabetic nephropathy [136]
doi:10.1227/01.neu.0000303197.87672.31 7
Comparison of the latch-helix binding pocket in the A-state (gray) with an eIF2-P-bound I-state (red) reveals the determinants of eIF2-P-stabilized latch-helix release (Fig
