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Frias JP, Davies MJ, Rosenstock J, et al
19 Of these compounds, celastrol was recognized as of particular interest because it was independently identified in five participating laboratories

And particularly, it seems particularly relevant for this as well, as we're always going past doughnut factories
Laughing gas and some medicines can also drain B12 levels

Nanotechnology and other biomarkers, such as soluble TREM could be helpful in this direction