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2023;133(5):e162315

Tian R, Tang S, Zhao J, et al

Researchers examine receptor signalling, hormonal communication, and feedback regulation within the endocrine system
In human embryonic kidney cells, persistent TNF- stimulation activates TET enzymes, which demethylate the CALCB enhancer and IL32 promoter, establishing a trained-like transcriptional state (170)

In this context, a diffusion barrier can serve as an effective strategy to mitigate these limitations and achieve more reliable sensor performance
