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Description

The GTPase superfamily: conserved structure and molecular mechanism

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Once generated, these ROS interact with PUFA tails of membrane phospholipids, as described previously

While the chronic ethanol ingestion period of the present experiment was shorter (47 days) than that of experiment 1, the rats showed a marked relapse intake to ethanol after two weeks of deprivation (alcohol reaccess on day 62), likely due to neuroinflammation and oxidative stress that self-perpetuate each other after ethanol is discontinued (see Israel et al., On the last 4 days of the 14-day ethanol deprivation period, rats were divided into five groups ( n = 6 rats/group): (1) LY341495/NAC group: rats were given LY341495, an inhibitor of the mGlu2/3 receptor, at a dose of 1 mg/kg per day (i.p.), 15 min before NAC administration (100 mg/kg per day by oral gavage (Fukumoto et al., via i.p