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and Larsen J., Bridging Clinical Radiotherapy and Space Radiation Therapeutics Through Reactive Oxygen Species (ROS)Triggered Delivery, Free Radical Biology and Medicine 219 (2024): 88103

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The TGF-1/Smad3 pathway is a key driver of this process, inducing the expression of fibrotic markers such as -SMA and collagen I, promoting interstitial remodeling