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Smith VM, Murphy R

Adams Harold E

We identify SLC33A1 , SNX17 , VPS35 , CLN, NPC2, and GRN, six genes with variants causing autosomal dominant forms of neurodegeneration, as genetic regulators of microglial lipid droplet formation, and we further validate the accumulation of LAM in GRN -/- mice, a model for frontotemporal dementia

Additionally, the proportion of B and T cells in the mammary gland decreases with age, indicating that changes in the immune environment may contribute to increased susceptibility to breast cancer