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doi: 10.2147/JIR.S432111 35 DexterDTWellsFRAgidFAgidYLeesAJJennerPet al

Solar light not only induces skin keratinocytes to secrete acetylcholine (ACh), which represses light-induced melanogenesis probably by inhibiting cAMP/CREB/MITF signaling in melanocytes 236 , 237 but also promotes expression of AChE in keratinocytes through transcription factor activator protein 1 (AP1) ex vivo 238

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