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These proteins are involved in the methionine cycle or subsequent methylation reactions: MAT2A catalyses the direct production of SAM (22, 23)

Cell 115:787798 Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J, Bartel DP, Linsley PS, Johnson JM (2005) Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

As such, there is a powerful need for chemical modification of proteins and the installation of non-natural functionality as a strategy for more free-ranging protein synthesis or design

A related construct, the Cardiorespiratory Digital Twin, does the same for oxygen transport and cardiovascular capacity the substrate that ultimately fuels the energy-hungry brain