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As a central transcription factor, NRF2 influences this cell death mode by inducing a variety of genes including SLC7A11, GPX4, FSP1, NQO1, HMOX1, ferritin heavy chain 1 (FTH1), HECT and RLD domain-containing E3 ubiquitin protein ligase 2, and vesicle-associated membrane protein 8 in hepatocellular carcinoma and ovarian cancer cells [85, 86]

86 Its anticancer properties stem from its interference with the initiation, proliferation, and metastasis of cancer cells

Injectable glutathione therapy should only be undertaken under the supervision of qualified healthcare providers who can assess individual appropriateness, monitor for adverse effects, and integrate glutathione therapy with comprehensive health management

[DOI] [PubMed] [Google Scholar] Lashuel HA, Overk CR, Oueslati A, Masliah E

Decreased NAD activates STAT3 and integrin pathways to drive epithelial-mesenchymal transition