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Description
Hyperinsulinemia drives diet-induced obesity independently of brain insulin production
A Phase 2 trial (NCT01311518) was designed to test RGN-352 in ~75 heart attack patients, but was placed on FDA clinical hold in 2011 due to manufacturing (GMP) compliance issues at the contract site not safety concerns with the drug itself
Calves, Swine, and Sheep: 5 mL per 100 pounds of body weight
Dopamine Effect: Testosterone is a hormone primarily produced in the testes in males and, to a lesser extent, in the ovaries and adrenal glands in females
It may upregulate growth hormone receptor expression in specific tissues such as tendon fibroblasts, which is a different mechanism from increasing systemic hormone levels
