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As the male population has a decrease in sperm count and a dramatic increase in infertility, observations suggest that testicular disease may be an important component of male infertility aetiology of promoting epigenetic transgenerational inheritance (Reference Sadler-Riggleman, Klukovich and Nilsson36)

doi: 10.1016/j.smallrumres.2025.107465 184

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A trial in 150 participants with either ovarian cancer or castration-resistant prostate cancer found no evidence that ALCAR (1g every 3 days) given with the anticancer drug sagopilone (for up to six cycles of treatment) reduced the overall risk of peripheral neuropathy compared to a placebo (90)