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Quick answer In the REDEFINE trials CagriSema is given once weekly by subcutaneous injection, with both components titrated in parallel from 0.25 mg + 0.25 mg up to a 2.4 mg + 2.4 mg weekly target
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In a phase I trial of CB-839 in relapsed leukemia, patients receiving CB-839 treatment usually showed grade 1 or 2 toxicities like transaminitis, thrombocytopenia, gastrointestinal events, and fatigue and about 1/3 (9/26) patients showed grade 3 or 4 toxicities like hematologic cytopenia [63]
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If the same researcher instead wanted a 2 mg/mL solution, the calculator would prescribe 2.5 mL of bacteriostatic water
