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A number of compounds with robust in vitro efficacy, such as DFO and certain natural products, fail to exert therapeutic effects in vivo due to their poor BBB permeability (139)

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[DOI] [PMC free article] [PubMed] [Google Scholar] [74].Pratico D

The analysis of oligonucleotides using MALDI-TOF-MS was first reported in 1990

In normoxia, pyruvate enters cellular mitochondria through the mitochondrial pyruvate carrier (MPC) to begin the second reaction phase of the aerobic oxidation pathway
