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The brains were removed from the skull with a postmortem delay of 110 h, frozen rapidly on dry ice, and stored at 80 C until microdissection

COPD is a chronic and uncontrolled inflammatory process that is perpetuated by continued exposure to cigarette smoke, oxidative stress, impaire/resolution pathways, and activation of immune cells [22]

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TNFR1 binds to several proteins, including tumor necrosis factor receptor type 1associated death domain (TRADD), TNFR1-associated receptor-interacting protein kinase, also called receptor-interacting protein kinase (RIPK), and TNF receptor-associated factor 2 (TRAF2) [208]

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