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This cycle is normally repeated only once every 6 months to allow the body to benefit from the cellular signaling without overstimulating the pineal gland

doi: 10.1155/2024/5518720 57 ThomuschOSekullaCBillmannFSeifertGDralleHLorenzKet al

However, the extent of its long-term safety in humans remains a subject of ongoing investigation

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MTHFR is vitamin B2 (riboflavin) dependent, and works to convert 5,10-methylenetetrahydrofolate (5,10-THF) to 5-Me-THF