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Although our review is focused on the use and, more importantly, the safety of these antioxidants in human clinical studies, we also highlighted those studies in different animal models that could complement the information obtained in the clinical area
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EV1B,C)
Although paraquat may not be an efficient inhibitor of mitochondrial complex I, and so does not affect dopamine uptake [87,88], it does cause -synuclein aggregation in C57Bl/6 mice, and alters Parkin solubility, decreasing proteasome activity and causing cellular damage [87]
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