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With this approach, these investigators revealed significant sex and estrus cycle differences and concluded that females were more sensitive to mechanical allodynia throughout the diestrus and pro-estrus phases [374]

The evidence for decline is most compelling in men: multiple studies report pronounced, sustained reductions in sperm count while motility and morphology show downward trends 12,13,14,15

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Figure 1 The MGE is the main source of cortical inhibitory interneurons, with its progenitor cells differentiating into PV and SST positive neurons

The production of norepinephrine, which can stimulate angiotensin-II production, which in turn influences BP, has been suggested as a possible mechanism for the increase in BP with IVB12 23