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17 Detection of elevated levels of these APAP-protein adducts by high-pressure liquid chromatography (HPLC) can be used for clinical indication of APAP hepatotoxicity

Acetaminophen Lipid peroxidation The hypothesis that LPO is the main cause of APAP hepatotoxicity was introduced by Wendel and coworkers 35 years ago, 38,5658 contrasting the previously established idea that protein binding of a reactive metabolite generated by cytochrome P450 is the key event in cell death

Therapeutic inhibition of IGF-1R or downstream AKT/ERK signalingcould therefore potentiate immune checkpoint therapy by restoring MHC-I presentation and reducing PD-L1 expression
10.1371/journal.pone.0082334 141

Sperandio S, de Belle I, Bredesen DE
