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Description
Since previous studies have linked the activation of NRF2 with the repression of lipogenic gene expression 64 , we reasoned that GSH depletion causes oxidation and consequent inactivation of KEAP1 (a repressor of NRF2), thus leading to increased antioxidant and decreased lipogenic gene expression

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Either way, the aggregated peptide is biologically inactive and cannot be recovered

Yamashita T, Budhu A, Forgues M, Wang XW

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