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In rats with bleomycin-induced pulmonary fibrosis, intragastric NAC treatment (250 mg/kg) improved the lung appearance, decreased the MDA content, increased the SOD content, and lowered the degrees of alveolar inflammatory cell infiltration and fibrosis, but even better were the results for the combination of NAC with intraperitoneal administration of the free radical scavenger edaravone (6 mg/kg) [163]

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