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Critical limitations identified in the systematic review include predominant use of small rodent models (primarily rats), short follow-up periods relative to human healing timelines, variable dosing regimens complicating dose-response assessment, and lack of standardized outcome measures across studies

doi: 10.1016/j.jsgi.2005.12.001

Noteworthy, each of these models has a particular target, and they are properly oriented as suited models, i.e., Parkinsons disease (MPTP, reserpine) [69], catalepsy (neuroleptics) [68,70], and schizophrenia (positive symptoms) (amphetamine) [70,152]

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Researchers studied that the best solution would be to mix the BP with ethyl esters of essential unsaturated fatty acids from flaxseeds