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5.3 Regulation of ferroptosis by natural products In recent years, ferroptosis has emerged as a critical focus in drug development

In the consumer sector, the "beauty-from-within" trend has catapulted L-Glutathione into prominence as a premier skin-whitening and anti-aging ingredient, particularly in Asia

Furthermore, succinate delivered via tumor-derived microvesicles triggers succinylation of isocitrate dehydrogenase 2 (IDH2) and histone H3K122, thereby enhancing lactate dehydrogenase A (LDHA) expression and forming a positive feedback loop that promotes glycolysis (134)

It also appears to play an integral role in maintaining normal ocular function

however, an effective pharmacological treatment has not yet been approved