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The compound was designed to provide both high IRAP inhibitory capacity and an improved metabolic stability attributed to the introduction of an -amino acid residue adjacent to the predicted scissile peptide bond
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PMID: 36 MatthewsDRHoskerJPRudenskiASNaylorBATreacherDFTurnerRC
This gene modulation capability extends to shifting gene expression in COPD lungs from a destructive state to one of healthy remodeling, showcasing its broad therapeutic potential 13

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