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Ipamorelin drives potent and dose-dependent GH release from pituitary somatotroph cells with selectivity equivalent to the most refined second-generation GH secretagogues , making it the primary research tool for studying GHS-R1a-mediated somatotroph biology where GH-specific downstream effects must be studied free from prolactin and cortisol co-secretion confounds

Nature 575(7784):693698