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glutathione peroxidase 4 amino acid sequence A white paper on Phospholipid Hydroperoxide (GPx4) forty years later Oxytosis/Ferroptosis in Neurodegeneration: the Underlying
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Garibov E, Taslimi P, Sujayev A, Bingl Z, etinkaya S, Gulcin I, Beydemir S, Farzaliyev V, Alwasel SH, Supuran CT (2016) Synthesis of 4,5-disubstituted-2-thioxo-1,2,3,4-tetrahydropyrimidines and investigation of their acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase I/II inhibitory and antioxidant activities

Apparently, the intraocular flux of at least some metabolites follows the same vitreal-aqueous gradient (see above), allowing the composition of retinal zinc-chelate complexes to be assessed by metabolomic analysis of AH

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Preclinical animal studies further validate its neuroprotective potential: phillyrin A improves learning and memory in senescence-accelerated mice, activates the Nrf2 signaling pathway in APP/PS1 mice, upregulates antioxidant proteins (NQO1, GPX4), and normalizes cerebral iron content through modulation of TFRC, DMT1, FTH, and FTL gene expression (234)
