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ACGS Best Practice Guidelines for Variant Classification in Rare Disease (ACGS, 2024)

"Multi-hit" TP53 mutations are significantly associated with high-risk disease features, such as complex karyotype (CK), and are linked to worse overall survival (OS) and disease-free survival compared to cases without TP53 mutations or with single-hit mutations [275]

[Accessed on 10th March 2026]

Asard, J

Deal with obesity Obesity in dogs is absolutely unacceptable and it's the number one root cause of hip and joint issues
