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72 Within GABAergic neurons, glutamate produced via PAG undergoes conversion to GABA catalyzed by the enzyme glutamic acid decarboxylase

Although the exact reasons are not known, we hypothesize that this could be an effect of the increased density and stiffness of the material, both of which have been shown in previous studies to have potentially detrimental impacts upon cellular migration and axonal elongation across nerve gaps 32,33,35,36,37

These findings indicate that the A172 cell line, associated with human glioblastoma, also displayed the ability to decrease ROS production upon treatment with 1-DNJ (Figure 6B)
