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Similarly, conditional knockout mice lacking Cacna1c in the cerebral cortex, which encodes the L-type, voltage-dependent, Ca 2+ -channel, alpha 1 C subunit that is among the most commonly identified risk genes for bipolar disorder, have reduced spontaneous cortical Ca 2+ activity and display hyperactive, manic-like behaviour [27, 28]

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[DOI] [PubMed] [Google Scholar] 146.Speciale SG

During the trial, four participants (one in Sequence A and three in Sequence B) were excluded from the final analysis (Figure 1)

In addition, these authors showed that acrolein was very effective in inhibiting the binding of NF-B1 (p50 subunit) to the IL-2 promoter using a chromatin immunoprecipitation assay