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Within the MAM, the ER and mitochondria are tethered together through the vesicle-associated membrane protein-associated protein B (VAPB) and the protein tyrosine kinase phosphatase interacting protein 51 (PTPIP51)

While early safety data appear favorable, the potential for proangiogenic activity to influence oncogenic processes underscores the importance of comprehensive cancer pre-screening prior to therapeutic use

Mannella, 1997

A growing body of evidence points towards the suggestion that intestinal dysbiosis contributes to impaired barrier function of the intestinal mucosa [191]
