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Alongside impaired autophagy, excessive ER stress possesses a pivotal part in the pathogenesis of neurological diseases including, neurodevelopmental disorders, as it enhances neuronal apoptosis (Coulson et al

Journal of Cell Biology 1994, 125 (4): 929943

Many of these diseases involve a significant inflammatory component in which C-C motif chemokine ligand 2 (CCL2), a chemokine secreted by monocytes, macrophages, and dendritic cells, attracts monocytes, T cells, and other leukocytes to a site of acute infection [50]

A growing list of genes have been associated with immune related functions critical to immunological response and much data is concluding it is the status of these genes that is key to immune response

#2 Methylcobalamin (Active B12) B12 is the cofactor for methionine synthase the enzyme at Step 3 on the Map that uses methylfolate to convert homocysteine back to methionine [1, 12]