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In SH-SY5Y cells stimulated with A 142 or 6-OHDA, DMF has been reported to increase cellular viability and reduce intracellular ROS production, both through the activation of HMOX-1, while a study treating ALS patient-derived macrophages demonstrated DMFs ability to inhibit pro-inflammatory cytokines as well as NF-kB (Table 1)

Significant decreases in depression severity in IN-NPY patients were observed at 5 and 24 h post-treatment, with a progressive decrease from the 5 to 24 h mark, though no significant differences from placebo were seen at 48 h [123]

Yang, Antidepressant effect of taurine in chronic unpredictable mild stress-induced depressive rats, Scientific Reports 7(1) (2017) 4989

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