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foxo4-dri senolytic study regulates endothelial cell senescence via the P53 signaling pathway FOXO4-DRI - Wikipedia
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Indeed, the phosphorylation of claudin-1 protected itself against ubiquitin-mediated destruction, preserving the TJ complex under osmotic stress, 208 while claudin-4 phosphorylation enhanced its interaction with occludin, augmenting TJ assembly

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