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However, when serine is available, neither restricting exogenous glycine intake nor depleting the endogenous glycine cleavage system can inhibit the proliferation of cancer cells, indicating that nucleotide synthesis and cancer cell growth are supported by serine rather than glycine consumption [171]

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Notably, flavin-containing monooxygenase 3 ( Fmo3 ), the enzyme responsible for TMAO production in the liver, was reduced in sepsis-associated AKI