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10.1016/j.jtemb.2016.06.007 106

doi: 10.1016/s0166-2236(02)02143-4
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Mechanism of Estrogens Effect on Melasma Estrogens, particularly estradiol (E2), estrone (E1), and estriol (E3), exhibit distinct molecular structures that influence their biological activity and bioavailability

Reviewing them before or during the meeting will give providers important insight into how FDA is currently weighing these substances
