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The severity and the reversibility of drug-induced ototoxicity depend on factors, such as dosage, duration of exposure, patient susceptibility, and concurrent use of other ototoxic agents (Steyger 2021b

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Histologically, melatonin did not fully prevent immune cell accumulation in the lung parenchyma when Luzindole was present, however, the extent of infiltration remained markedly reduced compared with IL-33 alone ( Figures 2D, E )

References Novo Nordisk presents phase 3 data for next-generation amylin cagrilintide, leading to advancement into dedicated clinical Programme, 16 September 2025, Novo Nordisk, DAscanio AM, Mullally JA, Frishman WH

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