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[1] [2] When neurological symptoms are present such as paraesthesia, numbness, balance problems, or cognitive changesmore aggressive treatment is required

This similarity of action by two activators which act on different portions of the channel subunit, and the congruence of the dose-response profiles for in vitro respiratory rhythm depression and activation of recombinant KCNQ channels, provides strong pharmacological evidence for involvement of KCNQ potassium channels in the modulation or generation of preBtC inspiratory rhythms

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