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Moreover, genetic and pharmacological inhibition of iron-related genes (e.g., HO-1 , TfR1 , and FTH1 , which encode heme oxygenase-1, transferrin receptor 1, and ferritin, respectively) can inhibit ferroptosis in tumor cells [54,55,56]
In the SLC7A11 systemic knockout mouse model, depletion of GSH levels was observed, but did not cause spontaneous hepatic iron deficiency, but rather increased sensitivity to ferroptosis [52]
doi: 10.1016/S1474-4422(05)70326-4, 71
