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Toxicity evaluations demonstrate an IC50 above 300 g/mL for joint cells and no adverse effects in 28-day in vivo studies

The therapeutic effect of curcumin to counteract certain complications during pregnancy, such as PE and FGR, has been tested in vitro studies, showing an increase in angiogenesis and a decrease in oxidative stress through activation of the Nrf2 signaling pathway [26,27]

Talanta 233 , 122469 (2021)

10.1094/MPMI-05-10-0110 90 LevineA.TenhakenR.DixonR.LambC

Antioxidant and anti-inflammatory effects: GHK-Cu exhibits potent antioxidant and anti-inflammatory properties, which can help protect the skin from oxidative stress and reduce inflammation associated with various skin conditions, such as acne, rosacea, and psoriasis