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Although pentavalent methylated arsenicals (MAs V , DMAs V , TMAs V ) are less toxic than inorganic ones (iAs V , iAs III ), the trivalent intermediated formed during the methylation process (MAs III , DMAs III ) are much more cytotoxic and genotoxic (Hughes, 2009)

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J Am Chem Soc 123: 56255631, 2001

In addition, their antifungal effects are relatively weak compared to standard fungicidal therapy, making them insufficient for the rapid fungal clearance required in cryptococcal meningitis