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The liver stores B12, and these stores can last a significant time (up to several years for non-deficient individuals), but when they are depleted, it takes consistent input to rebuild and maintain them

2+ gets access into the mitochondria, and opens the mitochondrial permeability transition pore (mPTP), water flows into the mitochondria, causing it to swell and undergo necrosis (Matsui et al

doi: 10.1016/j.fsi.2016.03.149
10.4103/1673-5374.211172 24 CervelliniI.GalinoJ.ZhuN.AllenS.BirchmeierC.BennettD
