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Diurnal variations in mood have been seen in naturalistic conditions ( Acute or chronic dysfunctions of the circadian timekeeping system (e.g., Eastbound travels across time-zones and rotating night shift workers, respectively) impact the organism with consequences at different biological scales, i.e., cellular, tissue, and systemic level

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Injectable protocols effectively aim to restore or exceed youthful plasma concentrations -- a goal impossible through topical application
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