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Finally, 0.5 mg of larazotide t.i.d., but not the higher doses, improved symptoms in CeD patients with persistent symptoms despite following a gluten-free diet (99)

The S1P receptor modulators fingolimod, siponimod, and ozanimod have been approved by regulators for treatment of multiple sclerosis, and ozanimod has also been studied for treatment of moderate-to-severe UC for up to 32 weeks

10.1016/j.neuint.2021.104972 Neurochem

Key Safety Differentiators No IGF-1 elevation: AOD-9604 does not stimulate IGF-1, meaning it avoids risks such as organ/tissue overgrowth or acromegaly No glucose disruption: Clinical data shows it does not impair insulin sensitivity or worsen blood sugar regulation Comparable to placebo: In obesity trials, the incidence of adverse effects was similar to placebo groups, underscoring its tolerability Legal Status of AOD-9604 United States: AOD-9604 is not FDA-approved as a drug, dietary supplement, or weight loss therapy