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These findings were confirmed in vivo, in nude mice bearing U937 tumours coinjected with recombinant hGH and the NF-B -inducing anticancer drug daunorubicin, to avoid the in vivo toxicity of TNF-

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The impaired transsulfuration pathway prevented homocysteine transsulfuration to cysteine, resulting in cysteine deficiency and subsequent reduction in GSH pool size