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Glutathione depletion is linked with Th2 polarization in mice with a retrovirus-induced immunodeficiency syndrome, murine AIDS: role of proglutathione molecules as immunotherapeutics

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The underlying mechanism involves AS-IVs ability to reduce mitochondrial ROS in myocardial cells of MI mice, inhibit NLRP3 inflammasome activation, and subsequently downregulate the expression of downstream inflammatory factors such as IL-18 and IL-1, along with the caspase-1 regulator involved in cell pyroptosis

Court MH, Dua SX, von Moltke LL, Greenblatt DJ, Patten CJ, Miners JO, MacKenzie PI: Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms